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1m6o
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1m6o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M6O FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m6o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M6O FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m6o RCSB], [http://www.ebi.ac.uk/pdbsum/1m6o PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m6o RCSB], [http://www.ebi.ac.uk/pdbsum/1m6o PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> | [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Brooks, A G | + | [[Category: Brooks, A G]] |
| - | [[Category: Clements, C S | + | [[Category: Clements, C S]] |
| - | [[Category: Ely, L K | + | [[Category: Ely, L K]] |
| - | [[Category: Gorman, J J | + | [[Category: Gorman, J J]] |
| - | [[Category: Kjer-Nielsen, L | + | [[Category: Kjer-Nielsen, L]] |
| - | [[Category: Koelle, D M | + | [[Category: Koelle, D M]] |
| - | [[Category: Lovrecz, G O | + | [[Category: Lovrecz, G O]] |
| - | [[Category: Lu, L | + | [[Category: Lu, L]] |
| - | [[Category: Macdonald, W A | + | [[Category: Macdonald, W A]] |
| - | [[Category: McCluskey, J | + | [[Category: McCluskey, J]] |
| - | [[Category: Mifsud, N A | + | [[Category: Mifsud, N A]] |
| - | [[Category: Purcell, A W | + | [[Category: Purcell, A W]] |
| - | [[Category: Rossjohn, J | + | [[Category: Rossjohn, J]] |
| - | [[Category: Williams, D S | + | [[Category: Williams, D S]] |
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Mhc i]] | [[Category: Mhc i]] | ||
Revision as of 15:45, 5 January 2015
Crystal Structure of HLA B*4402 in complex with HLA DPA*0201 peptide
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Categories: Homo sapiens | Brooks, A G | Clements, C S | Ely, L K | Gorman, J J | Kjer-Nielsen, L | Koelle, D M | Lovrecz, G O | Lu, L | Macdonald, W A | McCluskey, J | Mifsud, N A | Purcell, A W | Rossjohn, J | Williams, D S | Glycoprotein | Immune system | Mhc i
