1n4m
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1n4m]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4M FirstGlance]. <br> | <table><tr><td colspan='2'>[[1n4m]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4M FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n4m RCSB], [http://www.ebi.ac.uk/pdbsum/1n4m PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n4m RCSB], [http://www.ebi.ac.uk/pdbsum/1n4m PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/E2F2_HUMAN E2F2_HUMAN]] Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Chang, J H | + | [[Category: Chang, J H]] |
| - | [[Category: Cho, Y | + | [[Category: Cho, Y]] |
| - | [[Category: Lee, C | + | [[Category: Lee, C]] |
| - | [[Category: Lee, H S | + | [[Category: Lee, H S]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Protein-peptide complex]] | [[Category: Protein-peptide complex]] | ||
Revision as of 00:05, 25 December 2014
Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2
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