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1t1t
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t1t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Parabuthus_transvaalicus Parabuthus transvaalicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T1T FirstGlance]. <br> | <table><tr><td colspan='2'>[[1t1t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Parabuthus_transvaalicus Parabuthus transvaalicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T1T FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t1t RCSB], [http://www.ebi.ac.uk/pdbsum/1t1t PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t1t RCSB], [http://www.ebi.ac.uk/pdbsum/1t1t PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KURT_PARTR KURT_PARTR]] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A. Also binds to Cav3.1/CACNA1G and Cav3.2/CACNA1H T-type calcium channels with high affinity and inhibits the channels by modifying voltage-dependent gating. Another study (PubMed:11896142) shows that it also targets neuronal high-threshold calcium channels, including P-type, N-type, and L-type calcium channels (Cav), and others that still are unidentified pharmacologically.<ref>PMID:10196582</ref> <ref>PMID:11896142</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Parabuthus transvaalicus]] | [[Category: Parabuthus transvaalicus]] | ||
| - | [[Category: Cho, E M | + | [[Category: Cho, E M]] |
| - | [[Category: Eu, Y J | + | [[Category: Eu, Y J]] |
| - | [[Category: Kim, J I | + | [[Category: Kim, J I]] |
| - | [[Category: Kohno, T | + | [[Category: Kohno, T]] |
| - | [[Category: Lee, C W | + | [[Category: Lee, C W]] |
| - | [[Category: Min, H J | + | [[Category: Min, H J]] |
[[Category: Cysteine stabilized alpha-beta]] | [[Category: Cysteine stabilized alpha-beta]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 00:07, 25 December 2014
Solution Structure of Kurtoxin
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