1gyw
From Proteopedia
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|PDB= 1gyw |SIZE=350|CAPTION= <scene name='initialview01'>1gyw</scene>, resolution 2.40Å | |PDB= 1gyw |SIZE=350|CAPTION= <scene name='initialview01'>1gyw</scene>, resolution 2.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyw OCA], [http://www.ebi.ac.uk/pdbsum/1gyw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gyw RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Miele, A E.]] | [[Category: Miele, A E.]] | ||
[[Category: Owen, D J.]] | [[Category: Owen, D J.]] | ||
| - | [[Category: CL]] | ||
[[Category: adaptor]] | [[Category: adaptor]] | ||
[[Category: coated pit]] | [[Category: coated pit]] | ||
[[Category: endocytosis]] | [[Category: endocytosis]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:13 2008'' |
Revision as of 17:54, 30 March 2008
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| , resolution 2.40Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1 A753D MUTANT
Overview
The AP1 complex is one of a family of heterotetrameric clathrin-adaptor complexes involved in vesicular trafficking between the Golgi and endosomes. The complex has two large subunits, gamma and beta1, which can be divided into trunk, hinge, and appendage domains. The 1.8 A resolution structure of the gamma appendage is presented. The binding site for the known gamma appendage ligand gamma-synergin is mapped through creation of point mutations designed on the basis of the structure. We also show that Eps15, a protein believed to be involved in vesicle formation at the plasma membrane, is also a ligand of gamma appendage and binds to the same site as gamma-synergin. This observation explains the demonstrated brefeldinA (BFA)-sensitive colocalization of Eps15 and AP1 at the Golgi complex.
About this Structure
1GYW is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin., Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ, Structure. 2002 Aug;10(8):1139-48. PMID:12176391
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