1jsm
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JSM FirstGlance]. <br> | <table><tr><td colspan='2'>[[1jsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JSM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jsi|1jsi]], [[1jsh|1jsh]], [[1jsd|1jsd]], [[1jsn|1jsn]], [[1jso|1jso]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jsi|1jsi]], [[1jsh|1jsh]], [[1jsd|1jsd]], [[1jsn|1jsn]], [[1jso|1jso]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jsm RCSB], [http://www.ebi.ac.uk/pdbsum/1jsm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jsm RCSB], [http://www.ebi.ac.uk/pdbsum/1jsm PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A5Z226_I97A2 A5Z226_I97A2]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013828_004_327643] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
| - | [[Category: Ha, Y | + | [[Category: Ha, Y]] |
| - | [[Category: Skehel, J J | + | [[Category: Skehel, J J]] |
| - | [[Category: Stevens, D J | + | [[Category: Stevens, D J]] |
| - | [[Category: Wiley, D C | + | [[Category: Wiley, D C]] |
[[Category: Fusion protein]] | [[Category: Fusion protein]] | ||
[[Category: Influenza]] | [[Category: Influenza]] | ||
[[Category: Receptor complex]] | [[Category: Receptor complex]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 13:58, 24 December 2014
STRUCTURE OF H5 AVIAN HAEMAGGLUTININ
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