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1s5q
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1s5q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S5Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[1s5q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S5Q FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g1e|1g1e]], [[1s5r|1s5r]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g1e|1g1e]], [[1s5r|1s5r]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sin3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sin3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s5q RCSB], [http://www.ebi.ac.uk/pdbsum/1s5q PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s5q RCSB], [http://www.ebi.ac.uk/pdbsum/1s5q PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MAD1_HUMAN MAD1_HUMAN]] Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. [[http://www.uniprot.org/uniprot/SIN3A_MOUSE SIN3A_MOUSE]] Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Cowley, S M | + | [[Category: Cowley, S M]] |
| - | [[Category: Eisenman, R N | + | [[Category: Eisenman, R N]] |
| - | [[Category: Huang, K | + | [[Category: Huang, K]] |
| - | [[Category: Kang, R S | + | [[Category: Kang, R S]] |
| - | [[Category: Knoepfler, P S | + | [[Category: Knoepfler, P S]] |
| - | [[Category: Laherty, C D | + | [[Category: Laherty, C D]] |
| - | [[Category: Radhakrishnan, I | + | [[Category: Radhakrishnan, I]] |
| - | [[Category: Swanson, K A | + | [[Category: Swanson, K A]] |
[[Category: Amphipathic helix motif]] | [[Category: Amphipathic helix motif]] | ||
[[Category: Four-helix bundle]] | [[Category: Four-helix bundle]] | ||
Revision as of 13:13, 25 December 2014
Solution Structure of Mad1 SID-mSin3A PAH2 Complex
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