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1rwi

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1rwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RWI FirstGlance]. <br>
<table><tr><td colspan='2'>[[1rwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RWI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rwl|1rwl]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rwl|1rwl]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PKND, RV0931C, MT0958, MTCY08C9.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PKND, RV0931C, MT0958, MTCY08C9.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rwi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rwi RCSB], [http://www.ebi.ac.uk/pdbsum/1rwi PDBsum], [http://www.topsan.org/Proteins/TBSGC/1rwi TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rwi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rwi RCSB], [http://www.ebi.ac.uk/pdbsum/1rwi PDBsum], [http://www.topsan.org/Proteins/TBSGC/1rwi TOPSAN]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PKND_MYCTU PKND_MYCTU]] Key microbial factor required for central nervous system tuberculosis. Required for invasion of host brain endothelia, but not macrophages, lung epithelia or other endothelia. Phosphorylates the anti-anti-sigma factor homolog Rv0516c, which inhibits binding of Rv0516c to Rv2638, another anti-anti-sigma factor. Can also phosphorylate the FHA domain of Rv1747.<ref>PMID:15987910</ref> <ref>PMID:17242402</ref> <ref>PMID:17411339</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Alber, T.]]
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[[Category: Alber, T]]
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[[Category: Good, M C.]]
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[[Category: Good, M C]]
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[[Category: Greenstein, A E.]]
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[[Category: Greenstein, A E]]
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[[Category: Ng, H L.]]
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[[Category: Ng, H L]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Young, T A.]]
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[[Category: Beta propeller]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Young, T A]]
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[[Category: Beta propeller]]
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[[Category: PSI, Protein structure initiative]]
[[Category: Tbsgc]]
[[Category: Tbsgc]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 16:07, 24 December 2014

Extracellular domain of Mycobacterium tuberculosis PknD

1rwi, resolution 1.80Å

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