1qjt
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1qjt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QJT FirstGlance]. <br> | <table><tr><td colspan='2'>[[1qjt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QJT FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qjt RCSB], [http://www.ebi.ac.uk/pdbsum/1qjt PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qjt RCSB], [http://www.ebi.ac.uk/pdbsum/1qjt PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EPS15_MOUSE EPS15_MOUSE]] Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Carotenuto, A | + | [[Category: Carotenuto, A]] |
| - | [[Category: Henegouwen, P M.Van Bergen En | + | [[Category: Henegouwen, P M.Van Bergen En]] |
| - | [[Category: Tessari, M | + | [[Category: Tessari, M]] |
| - | [[Category: Vuister, G W | + | [[Category: Vuister, G W]] |
| - | [[Category: Whitehead, B | + | [[Category: Whitehead, B]] |
[[Category: Ef-hand]] | [[Category: Ef-hand]] | ||
[[Category: Eh domain]] | [[Category: Eh domain]] | ||
Revision as of 21:14, 24 December 2014
SOLUTION STRUCTURE OF THE APO EH1 DOMAIN OF MOUSE EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15, EPS15
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