1gf8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1gf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GF8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1gf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GF8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gay|1gay]], [[1gf9|1gf9]], [[1gfa|1gfa]], [[1gfe|1gfe]], [[1gfg|1gfg]], [[1gfh|1gfh]], [[1gfj|1gfj]], [[1gfk|1gfk]], [[1gfr|1gfr]], [[1gft|1gft]], [[1gfu|1gfu]], [[1gfv|1gfv]], [[1inu|1inu]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gay|1gay]], [[1gf9|1gf9]], [[1gfa|1gfa]], [[1gfe|1gfe]], [[1gfg|1gfg]], [[1gfh|1gfh]], [[1gfj|1gfj]], [[1gfk|1gfk]], [[1gfr|1gfr]], [[1gft|1gft]], [[1gfu|1gfu]], [[1gfv|1gfv]], [[1inu|1inu]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gf8 RCSB], [http://www.ebi.ac.uk/pdbsum/1gf8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gf8 RCSB], [http://www.ebi.ac.uk/pdbsum/1gf8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN]] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[http://omim.org/entry/105200 105200]]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref> | [[http://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN]] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[http://omim.org/entry/105200 105200]]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref> | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Lysozyme]] | [[Category: Lysozyme]] | ||
| - | [[Category: Funahashi, J | + | [[Category: Funahashi, J]] |
| - | [[Category: Takano, K | + | [[Category: Takano, K]] |
| - | [[Category: Yamagata, Y | + | [[Category: Yamagata, Y]] |
| - | [[Category: Yutani, K | + | [[Category: Yutani, K]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Hydrophilic]] | [[Category: Hydrophilic]] | ||
[[Category: Stability]] | [[Category: Stability]] | ||
[[Category: Surface]] | [[Category: Surface]] | ||
Revision as of 00:13, 23 December 2014
CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
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Categories: Homo sapiens | Lysozyme | Funahashi, J | Takano, K | Yamagata, Y | Yutani, K | Hydrolase | Hydrophilic | Stability | Surface
