1x7b
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1x7b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X7B FirstGlance]. <br> | <table><tr><td colspan='2'>[[1x7b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X7B FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=041:2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL'>041</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=041:2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL'>041</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u3q|1u3q]], [[1u3r|1u3r]], [[1u3s|1u3s]], [[1u9e|1u9e]], [[1x76|1x76]], [[1x78|1x78]], [[1x7j|1x7j]], [[1x7r|1x7r]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u3q|1u3q]], [[1u3r|1u3r]], [[1u3s|1u3s]], [[1u9e|1u9e]], [[1x76|1x76]], [[1x78|1x78]], [[1x7j|1x7j]], [[1x7r|1x7r]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESR2, NR3A2, ESTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESR2, NR3A2, ESTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x7b RCSB], [http://www.ebi.ac.uk/pdbsum/1x7b PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x7b RCSB], [http://www.ebi.ac.uk/pdbsum/1x7b PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 34: | Line 36: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Akopian, T | + | [[Category: Akopian, T]] |
| - | [[Category: Alvarez, J C | + | [[Category: Alvarez, J C]] |
| - | [[Category: Bapat, A | + | [[Category: Bapat, A]] |
| - | [[Category: Bhat, R A | + | [[Category: Bhat, R A]] |
| - | [[Category: Harris, H A | + | [[Category: Harris, H A]] |
| - | [[Category: Hsiao, C | + | [[Category: Hsiao, C]] |
| - | [[Category: Hum, W T | + | [[Category: Hum, W T]] |
| - | [[Category: Malakian, K | + | [[Category: Malakian, K]] |
| - | [[Category: Malamas, M S | + | [[Category: Malamas, M S]] |
| - | [[Category: Manas, E S | + | [[Category: Manas, E S]] |
| - | [[Category: Miller, C P | + | [[Category: Miller, C P]] |
| - | [[Category: Somers, W S | + | [[Category: Somers, W S]] |
| - | [[Category: Stahl, M L | + | [[Category: Stahl, M L]] |
| - | [[Category: Unwalla, R J | + | [[Category: Unwalla, R J]] |
| - | [[Category: Wolfrom, S | + | [[Category: Wolfrom, S]] |
| - | [[Category: Xu, Z B | + | [[Category: Xu, Z B]] |
[[Category: Agonist]] | [[Category: Agonist]] | ||
[[Category: Er]] | [[Category: Er]] | ||
Revision as of 19:05, 25 December 2014
CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041
| |||||||||||
Categories: Homo sapiens | Akopian, T | Alvarez, J C | Bapat, A | Bhat, R A | Harris, H A | Hsiao, C | Hum, W T | Malakian, K | Malamas, M S | Manas, E S | Miller, C P | Somers, W S | Stahl, M L | Unwalla, R J | Wolfrom, S | Xu, Z B | Agonist | Er | Er-beta | Estrogen | Estrogen receptor | Estrogen receptor beta | Nuclear receptor | Transcription | Transcription factor
