1vdg
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br> | <table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g0x|1g0x]], [[1ufu|1ufu]], [[1ugn|1ugn]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g0x|1g0x]], [[1ufu|1ufu]], [[1ugn|1ugn]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Leukocyte immunoglobulin-like receptor|Leukocyte immunoglobulin-like receptor]] | *[[Leukocyte immunoglobulin-like receptor|Leukocyte immunoglobulin-like receptor]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Amano, K | + | [[Category: Amano, K]] |
| - | [[Category: Kohda, D | + | [[Category: Kohda, D]] |
| - | [[Category: Kuroki, K | + | [[Category: Kuroki, K]] |
| - | [[Category: Maenaka, K | + | [[Category: Maenaka, K]] |
| - | [[Category: Rasubala, L | + | [[Category: Rasubala, L]] |
| - | [[Category: Shiroishi, M | + | [[Category: Shiroishi, M]] |
| - | [[Category: Tokunaga, K | + | [[Category: Tokunaga, K]] |
| - | [[Category: Tsuchiya, N | + | [[Category: Tsuchiya, N]] |
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Immunoglobulin-like]] | [[Category: Immunoglobulin-like]] | ||
Revision as of 03:01, 25 December 2014
Crystal structure of LIR1.01, one of the alleles of LIR1
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