1z1m

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1z1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z1M FirstGlance]. <br>
<table><tr><td colspan='2'>[[1z1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z1M FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z1m RCSB], [http://www.ebi.ac.uk/pdbsum/1z1m PDBsum]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z1m RCSB], [http://www.ebi.ac.uk/pdbsum/1z1m PDBsum]</span></td></tr>
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<table>
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</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barlow, P N.]]
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[[Category: Barlow, P N]]
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[[Category: Fischer, P.]]
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[[Category: Fischer, P]]
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[[Category: McInnes, C.]]
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[[Category: McInnes, C]]
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[[Category: Powers, H.]]
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[[Category: Powers, H]]
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[[Category: Uhrin, D.]]
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[[Category: Uhrin, D]]
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[[Category: Uhrinova, S.]]
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[[Category: Uhrinova, S]]
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[[Category: Watt, K.]]
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[[Category: Watt, K]]
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[[Category: Zheleva, D.]]
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[[Category: Zheleva, D]]
[[Category: Alpha-beta domain]]
[[Category: Alpha-beta domain]]
[[Category: Ligase]]
[[Category: Ligase]]
[[Category: Peptide-binding groove]]
[[Category: Peptide-binding groove]]
[[Category: Psudosymmetry]]
[[Category: Psudosymmetry]]

Revision as of 10:30, 8 January 2015

NMR structure of unliganded MDM2

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