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1z1m
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1z1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z1M FirstGlance]. <br> | <table><tr><td colspan='2'>[[1z1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z1M FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z1m RCSB], [http://www.ebi.ac.uk/pdbsum/1z1m PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z1m RCSB], [http://www.ebi.ac.uk/pdbsum/1z1m PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | [[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Barlow, P N | + | [[Category: Barlow, P N]] |
| - | [[Category: Fischer, P | + | [[Category: Fischer, P]] |
| - | [[Category: McInnes, C | + | [[Category: McInnes, C]] |
| - | [[Category: Powers, H | + | [[Category: Powers, H]] |
| - | [[Category: Uhrin, D | + | [[Category: Uhrin, D]] |
| - | [[Category: Uhrinova, S | + | [[Category: Uhrinova, S]] |
| - | [[Category: Watt, K | + | [[Category: Watt, K]] |
| - | [[Category: Zheleva, D | + | [[Category: Zheleva, D]] |
[[Category: Alpha-beta domain]] | [[Category: Alpha-beta domain]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Peptide-binding groove]] | [[Category: Peptide-binding groove]] | ||
[[Category: Psudosymmetry]] | [[Category: Psudosymmetry]] | ||
Revision as of 10:30, 8 January 2015
NMR structure of unliganded MDM2
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