1yfn
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br> | <table><tr><td colspan='2'>[[1yfn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YFN FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ou8|1ou8]], [[1ou9|1ou9]], [[1oul|1oul]], [[1ox8|1ox8]], [[1ox9|1ox9]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ou8|1ou8]], [[1ou9|1ou9]], [[1oul|1oul]], [[1ox8|1ox8]], [[1ox9|1ox9]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yfn RCSB], [http://www.ebi.ac.uk/pdbsum/1yfn PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SSPB_ECOLI SSPB_ECOLI]] Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.<ref>PMID:11009422</ref> <ref>PMID:15371343</ref> <ref>PMID:12887894</ref> [[http://www.uniprot.org/uniprot/RSEA_ECOLI RSEA_ECOLI]] Negative regulator of RpoE. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Baker, T A | + | [[Category: Baker, T A]] |
| - | [[Category: Flynn, J M | + | [[Category: Flynn, J M]] |
| - | [[Category: Grant, R A | + | [[Category: Grant, R A]] |
| - | [[Category: Levchenko, I | + | [[Category: Levchenko, I]] |
| - | [[Category: Sauer, R T | + | [[Category: Sauer, R T]] |
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Protein-peptide complex]] | [[Category: Protein-peptide complex]] | ||
[[Category: Rsea]] | [[Category: Rsea]] | ||
[[Category: Sspb]] | [[Category: Sspb]] | ||
Revision as of 03:33, 25 December 2014
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex
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