1t4e

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1t4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4E FirstGlance]. <br>
<table><tr><td colspan='2'>[[1t4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T4E FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIZ:(4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC+ACID'>DIZ</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIZ:(4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC+ACID'>DIZ</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rv1|1rv1]], [[1ycr|1ycr]], [[1t4f|1t4f]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rv1|1rv1]], [[1ycr|1ycr]], [[1t4f|1t4f]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4e RCSB], [http://www.ebi.ac.uk/pdbsum/1t4e PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t4e RCSB], [http://www.ebi.ac.uk/pdbsum/1t4e PDBsum]</span></td></tr>
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<table>
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</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Carver, T E.]]
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[[Category: Carver, T E]]
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[[Category: Franks, C F.]]
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[[Category: Franks, C F]]
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[[Category: Grasberger, B L.]]
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[[Category: Grasberger, B L]]
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[[Category: Koblish, H K.]]
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[[Category: Koblish, H K]]
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[[Category: LaFrance, L V.]]
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[[Category: LaFrance, L V]]
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[[Category: Lu, T.]]
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[[Category: Lu, T]]
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[[Category: Parks, D J.]]
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[[Category: Parks, D J]]
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[[Category: Schubert, C.]]
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[[Category: Schubert, C]]
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[[Category: Zhao, S Y.]]
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[[Category: Zhao, S Y]]
[[Category: Ligase]]
[[Category: Ligase]]
[[Category: Mdm2-inhibitor complex]]
[[Category: Mdm2-inhibitor complex]]

Revision as of 06:50, 6 January 2015

Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor

1t4e, resolution 2.60Å

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