1tqb
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tqb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQB FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tqb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TQB FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tqc|1tqc]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tqc|1tqc]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRNP sheep VRQ variant ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9940 Ovis aries])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRNP sheep VRQ variant ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9940 Ovis aries])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tqb RCSB], [http://www.ebi.ac.uk/pdbsum/1tqb PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tqb RCSB], [http://www.ebi.ac.uk/pdbsum/1tqb PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/PRIO_SHEEP PRIO_SHEEP]] Note=Polymorphism at position 171 may be related to the alleles of scrapie incubation-control (SIC) gene in this species. Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. Note=Scrapie is a transmissible neurodegenerative disorder of sheep and goats. Most sheep that contract the disease naturally die between 24 and 50 months of age. The incubation period in sheep depends on the strain(s) of the infecting pathogen, sheep age at exposure, and the sheep genotype. The survival time is mainly determined by a single genetic locus, SIP, which has two alleles, susceptible (sa) and resistant (pa). Short incubation period is conferred by the partially dominant sa allele. Scrapie can be spread between flockmates, or it can be transmitted from an infected ewe to its lamb. | [[http://www.uniprot.org/uniprot/PRIO_SHEEP PRIO_SHEEP]] Note=Polymorphism at position 171 may be related to the alleles of scrapie incubation-control (SIC) gene in this species. Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. Note=Scrapie is a transmissible neurodegenerative disorder of sheep and goats. Most sheep that contract the disease naturally die between 24 and 50 months of age. The incubation period in sheep depends on the strain(s) of the infecting pathogen, sheep age at exposure, and the sheep genotype. The survival time is mainly determined by a single genetic locus, SIP, which has two alleles, susceptible (sa) and resistant (pa). Short incubation period is conferred by the partially dominant sa allele. Scrapie can be spread between flockmates, or it can be transmitted from an infected ewe to its lamb. | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Ovis aries]] | [[Category: Ovis aries]] | ||
| - | [[Category: Debey, P | + | [[Category: Debey, P]] |
| - | [[Category: Doublet, B | + | [[Category: Doublet, B]] |
| - | [[Category: Eghiaian, F | + | [[Category: Eghiaian, F]] |
| - | [[Category: Grosclaude, J | + | [[Category: Grosclaude, J]] |
| - | [[Category: Knossow, M | + | [[Category: Knossow, M]] |
| - | [[Category: Rezaei, H | + | [[Category: Rezaei, H]] |
| - | [[Category: Treguer, E | + | [[Category: Treguer, E]] |
[[Category: Antibody]] | [[Category: Antibody]] | ||
[[Category: Prion]] | [[Category: Prion]] | ||
[[Category: Unknown function-immune system complex]] | [[Category: Unknown function-immune system complex]] | ||
Revision as of 12:51, 6 January 2015
Ovine recombinant PrP(114-234), VRQ variant in complex with the Fab of the VRQ14 antibody
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