1wr7
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wr7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1wr7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR7 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wr3|1wr3]], [[1wr4|1wr4]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wr3|1wr3]], [[1wr4|1wr4]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wr7 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr7 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wr7 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr7 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NED4L_MOUSE NED4L_MOUSE]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.<ref>PMID:11149908</ref> <ref>PMID:12424229</ref> <ref>PMID:11742982</ref> <ref>PMID:11244092</ref> <ref>PMID:15123669</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Booker, G W | + | [[Category: Booker, G W]] |
| - | [[Category: Kowalski, K | + | [[Category: Kowalski, K]] |
| - | [[Category: Merkel, A L | + | [[Category: Merkel, A L]] |
[[Category: All-beta]] | [[Category: All-beta]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 18:53, 24 December 2014
Solution structure of the third WW domain of Nedd4-2
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