1xi3

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xi3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XI3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xi3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XI3 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thiE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thiE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-phosphate_diphosphorylase Thiamine-phosphate diphosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.3 2.5.1.3] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-phosphate_diphosphorylase Thiamine-phosphate diphosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.3 2.5.1.3] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xi3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xi3 PDBsum], [http://www.topsan.org/Proteins/SECSG/1xi3 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xi3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xi3 PDBsum], [http://www.topsan.org/Proteins/SECSG/1xi3 TOPSAN]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/THIE_PYRFU THIE_PYRFU]] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Thiamine-phosphate diphosphorylase]]
[[Category: Thiamine-phosphate diphosphorylase]]
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[[Category: Adams, M W.W.]]
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[[Category: Adams, M W.W]]
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[[Category: Chang, S H.]]
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[[Category: Chang, S H]]
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[[Category: Chen, L.]]
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[[Category: Chen, L]]
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[[Category: Dillard, B D.]]
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[[Category: Dillard, B D]]
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[[Category: Eneh, J C.]]
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[[Category: Eneh, J C]]
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[[Category: Habel, J.]]
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[[Category: Habel, J]]
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[[Category: Hopkins, R C.]]
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[[Category: Hopkins, R C]]
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[[Category: II, F L.Poole.]]
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[[Category: II, F L.Poole]]
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[[Category: III, W B.Arendall.]]
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[[Category: III, W B.Arendall]]
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[[Category: Jenney, F E.]]
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[[Category: Jenney, F E]]
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[[Category: Kelley, L L.C.]]
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[[Category: Kelley, L L.C]]
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[[Category: Lee, D.]]
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[[Category: Lee, D]]
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[[Category: Lee, H S.]]
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[[Category: Lee, H S]]
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[[Category: Li, T.]]
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[[Category: Li, T]]
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[[Category: Lin, D.]]
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[[Category: Lin, D]]
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[[Category: Liu, Z J.]]
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[[Category: Liu, Z J]]
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[[Category: Richardson, D C.]]
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[[Category: Richardson, D C]]
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[[Category: Richardson, J S.]]
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[[Category: Richardson, J S]]
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[[Category: Rose, J P.]]
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[[Category: Rose, J P]]
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[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]]
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[[Category: Structural genomic]]
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[[Category: Shah, C.]]
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[[Category: Shah, C]]
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[[Category: Sugar, F J.]]
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[[Category: Sugar, F J]]
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[[Category: Tempel, W.]]
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[[Category: Tempel, W]]
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[[Category: Wang, B C.]]
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[[Category: Wang, B C]]
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[[Category: Zhou, W.]]
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[[Category: Zhou, W]]
[[Category: Hyperthermophile]]
[[Category: Hyperthermophile]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Pyrococcus furiosus]]
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[[Category: Secsg]]
[[Category: Secsg]]
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[[Category: Southeast collaboratory for structural genomic]]
 
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[[Category: Structural genomic]]
 
[[Category: Thiamine phosphate pyrophosphorylase]]
[[Category: Thiamine phosphate pyrophosphorylase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 04:33, 25 December 2014

Thiamine phosphate pyrophosphorylase from Pyrococcus furiosus Pfu-1255191-001

1xi3, resolution 1.70Å

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