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1hei

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|PDB= 1hei |SIZE=350|CAPTION= <scene name='initialview01'>1hei</scene>, resolution 2.1&Aring;
|PDB= 1hei |SIZE=350|CAPTION= <scene name='initialview01'>1hei</scene>, resolution 2.1&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hei OCA], [http://www.ebi.ac.uk/pdbsum/1hei PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hei RCSB]</span>
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[[Category: Weber, P.]]
[[Category: Weber, P.]]
[[Category: Yao, N.]]
[[Category: Yao, N.]]
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[[Category: CA]]
 
[[Category: atpase]]
[[Category: atpase]]
[[Category: hcv]]
[[Category: hcv]]
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[[Category: rna]]
[[Category: rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:36:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:03:30 2008''

Revision as of 18:03, 30 March 2008

Image:1hei.gif


PDB ID 1hei

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE HEPATITIS C VIRUS RNA HELICASE DOMAIN


Overview

Helicases are nucleotide triphosphate (NTP)-dependent enzymes responsible for unwinding duplex DNA and RNA during genomic replication. The 2.1 A resolution structure of the HCV helicase from the positive-stranded RNA hepatitis C virus reveals a molecule with distinct NTPase and RNA binding domains. The structure supports a mechanism of helicase activity involving initial recognition of the requisite 3' single-stranded region on the nucleic acid substrate by a conserved arginine-rich sequence on the RNA binding domain. Comparison of crystallographically independent molecules shows that rotation of the RNA binding domain involves conformational changes within a conserved TATPP sequence and untwisting of an extended antiparallel beta-sheet. Location of the TATPP sequence at the end of an NTPase domain beta-strand structurally homologous to the 'switch region' of many NTP-dependent enzymes offers the possibility that domain rotation is coupled to NTP hydrolysis in the helicase catalytic cycle.

About this Structure

1HEI is a Single protein structure of sequence from Hepatitis c virus genotype 1a (isolate 1). Full crystallographic information is available from OCA.

Reference

Structure of the hepatitis C virus RNA helicase domain., Yao N, Hesson T, Cable M, Hong Z, Kwong AD, Le HV, Weber PC, Nat Struct Biol. 1997 Jun;4(6):463-7. PMID:9187654

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