1y2o
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br> | <table><tr><td colspan='2'>[[1y2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2O FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2o RCSB], [http://www.ebi.ac.uk/pdbsum/1y2o PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bompard, G | + | [[Category: Bompard, G]] |
| - | [[Category: Dafforn, T R | + | [[Category: Dafforn, T R]] |
| - | [[Category: Futterer, K | + | [[Category: Futterer, K]] |
| - | [[Category: Heung, M Y | + | [[Category: Heung, M Y]] |
| - | [[Category: Machesky, L M | + | [[Category: Machesky, L M]] |
| - | [[Category: Millard, T H | + | [[Category: Millard, T H]] |
| - | [[Category: Scott, D J | + | [[Category: Scott, D J]] |
[[Category: Actin bundling]] | [[Category: Actin bundling]] | ||
[[Category: Cell motility]] | [[Category: Cell motility]] | ||
[[Category: Filopodia]] | [[Category: Filopodia]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 20:12, 24 December 2014
Structure of N-terminal domain IRSp53/BAIAP2
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