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1u4m
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1u4m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U4M FirstGlance]. <br> | <table><tr><td colspan='2'>[[1u4m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U4M FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=H3S:HEPARIN+DISACCHARIDE+III-S'>H3S</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=H3S:HEPARIN+DISACCHARIDE+III-S'>H3S</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hrj|1hrj]], [[1rtn|1rtn]], [[1rto|1rto]], [[1b3a|1b3a]], [[1eqt|1eqt]], [[1u4r|1u4r]], [[1u4l|1u4l]], [[1u4p|1u4p]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hrj|1hrj]], [[1rtn|1rtn]], [[1rto|1rto]], [[1b3a|1b3a]], [[1eqt|1eqt]], [[1u4r|1u4r]], [[1u4l|1u4l]], [[1u4p|1u4p]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL5, SCYA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL5, SCYA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u4m RCSB], [http://www.ebi.ac.uk/pdbsum/1u4m PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u4m RCSB], [http://www.ebi.ac.uk/pdbsum/1u4m PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CCL5_HUMAN CCL5_HUMAN]] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.<ref>PMID:16791620</ref> <ref>PMID:1380064</ref> <ref>PMID:8525373</ref> <ref>PMID:9516414</ref> <ref>PMID:15923218</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Borlat, F | + | [[Category: Borlat, F]] |
| - | [[Category: Harrenga, A | + | [[Category: Harrenga, A]] |
| - | [[Category: Johnson, Z | + | [[Category: Johnson, Z]] |
| - | [[Category: Kungl, A | + | [[Category: Kungl, A]] |
| - | [[Category: Proudfoot, A E.I | + | [[Category: Proudfoot, A E.I]] |
| - | [[Category: Roulin, K | + | [[Category: Roulin, K]] |
| - | [[Category: Shaw, J P | + | [[Category: Shaw, J P]] |
| - | [[Category: Wells, T N.C | + | [[Category: Wells, T N.C]] |
| - | [[Category: Zwahlen, C | + | [[Category: Zwahlen, C]] |
[[Category: Attractant]] | [[Category: Attractant]] | ||
[[Category: Chemoattractant]] | [[Category: Chemoattractant]] | ||
Revision as of 21:36, 25 December 2014
human RANTES complexed to heparin-derived disaccharide III-S
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