1y60
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1y60]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens Methylobacterium extorquens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y60 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1y60]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens Methylobacterium extorquens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y60 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4M:5,10-DIMETHYLENE+TETRAHYDROMETHANOPTERIN'>H4M</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4M:5,10-DIMETHYLENE+TETRAHYDROMETHANOPTERIN'>H4M</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y5y|1y5y]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y5y|1y5y]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fae ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=408 Methylobacterium extorquens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fae ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=408 Methylobacterium extorquens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y60 RCSB], [http://www.ebi.ac.uk/pdbsum/1y60 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y60 RCSB], [http://www.ebi.ac.uk/pdbsum/1y60 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FAE_METEX FAE_METEX]] Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium.<ref>PMID:11073907</ref> <ref>PMID:15632161</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Methylobacterium extorquens]] | [[Category: Methylobacterium extorquens]] | ||
| - | [[Category: Acharya, P | + | [[Category: Acharya, P]] |
| - | [[Category: Demmer, U | + | [[Category: Demmer, U]] |
| - | [[Category: Ermler, U | + | [[Category: Ermler, U]] |
| - | [[Category: Goenrich, M | + | [[Category: Goenrich, M]] |
| - | [[Category: Hagemeier, C H | + | [[Category: Hagemeier, C H]] |
| - | [[Category: Thauer, R K | + | [[Category: Thauer, R K]] |
| - | [[Category: Vorholt, J A | + | [[Category: Vorholt, J A]] |
[[Category: Beta-alpha-beta left handed crossover]] | [[Category: Beta-alpha-beta left handed crossover]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Pentamer]] | [[Category: Pentamer]] | ||
[[Category: Tetrahydromethanopterin-binding]] | [[Category: Tetrahydromethanopterin-binding]] | ||
Revision as of 17:57, 25 December 2014
Structure of the tetrahydromethanopterin dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1 with bound 5,10-methylene tetrahydromethanopterin
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