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1t7e
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T7E FirstGlance]. <br> | <table><tr><td colspan='2'>[[1t7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T7E FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sn1|1sn1]], [[1t7a|1t7a]], [[1t7b|1t7b]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sn1|1sn1]], [[1t7a|1t7a]], [[1t7b|1t7b]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BmK M1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34649 Mesobuthus martensii])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BmK M1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34649 Mesobuthus martensii])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t7e RCSB], [http://www.ebi.ac.uk/pdbsum/1t7e PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t7e RCSB], [http://www.ebi.ac.uk/pdbsum/1t7e PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SCX1_MESMA SCX1_MESMA]] This alpha-like toxin binds voltage-dependently sodium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals and insects. Is active on Nav1.4/SCN4A and Nav1.5/SCN5A. Acts as a cardiotoxin. Is 6-fold more toxic than BmK-M2.<ref>PMID:11322948</ref> <ref>PMID:12705833</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
| - | [[Category: Guan, R J | + | [[Category: Guan, R J]] |
| - | [[Category: He, X L | + | [[Category: He, X L]] |
| - | [[Category: Sundberg, E J | + | [[Category: Sundberg, E J]] |
| - | [[Category: Wang, C G | + | [[Category: Wang, C G]] |
| - | [[Category: Wang, D C | + | [[Category: Wang, D C]] |
| - | [[Category: Wang, M | + | [[Category: Wang, M]] |
| - | [[Category: Xiang, Y | + | [[Category: Xiang, Y]] |
| - | [[Category: Zhang, Y | + | [[Category: Zhang, Y]] |
[[Category: Bmk m1 mutant]] | [[Category: Bmk m1 mutant]] | ||
[[Category: Buthus martensii karsch]] | [[Category: Buthus martensii karsch]] | ||
[[Category: Scorpion toxin]] | [[Category: Scorpion toxin]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 21:09, 24 December 2014
Crystal structure of mutant Pro9Ser of scorpion alpha-like neurotoxin BmK M1 from Buthus martensii Karsch
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