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1xc5
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XC5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1xc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XC5 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1xc5 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1xc5 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Codina, A | + | [[Category: Codina, A]] |
| - | [[Category: Lazar, M A | + | [[Category: Lazar, M A]] |
| - | [[Category: Li, Y | + | [[Category: Li, Y]] |
| - | [[Category: Love, J D | + | [[Category: Love, J D]] |
| - | [[Category: Neuhaus, D | + | [[Category: Neuhaus, D]] |
| - | [[Category: Schwabe, J W.R | + | [[Category: Schwabe, J W.R]] |
[[Category: Four-helix structure]] | [[Category: Four-helix structure]] | ||
[[Category: Three-helix triangle]] | [[Category: Three-helix triangle]] | ||
[[Category: Transcription corepressor]] | [[Category: Transcription corepressor]] | ||
Revision as of 06:15, 25 December 2014
Solution Structure of the SMRT Deacetylase Activation Domain
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