1ta3
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ta3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans] and [http://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TA3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ta3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans] and [http://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TA3 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1te1|1te1]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1te1|1te1]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XLNC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=162425 Emericella nidulans])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XLNC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=162425 Emericella nidulans])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ta3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ta3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ta3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ta3 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ta3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ta3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ta3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ta3 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/XIP1_WHEAT XIP1_WHEAT]] Fungal xylanase inhibitor. Possesses competitive inhibiting activity against fungal endo-1,4-beta-D-xylanases belonging to glycoside hydrolase family 10 (GH10) and family 11 (GH11). Possesses also inhibitory activity towards barley alpha-amylases. Binding to xylanases or amylases is necessary for inhibition activity. May function in plant defense against secreted fungal pathogen xylanases. Is similar to class III chitinases, but does not exhibit chitinase activity.<ref>PMID:12023019</ref> <ref>PMID:10024521</ref> <ref>PMID:11955286</ref> <ref>PMID:12922177</ref> [[http://www.uniprot.org/uniprot/XYNC_EMENI XYNC_EMENI]] Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.<ref>PMID:8917072</ref> <ref>PMID:16844780</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Endo-1,4-beta-xylanase]] | [[Category: Endo-1,4-beta-xylanase]] | ||
[[Category: Triticum aestivum]] | [[Category: Triticum aestivum]] | ||
| - | [[Category: Durand, A | + | [[Category: Durand, A]] |
| - | [[Category: Furniss, C | + | [[Category: Furniss, C]] |
| - | [[Category: Gilbert, H J | + | [[Category: Gilbert, H J]] |
| - | [[Category: Juge, N | + | [[Category: Juge, N]] |
| - | [[Category: Leone, P | + | [[Category: Leone, P]] |
| - | [[Category: Manzanares, P | + | [[Category: Manzanares, P]] |
| - | [[Category: Payan, F | + | [[Category: Payan, F]] |
| - | [[Category: Porciero, S | + | [[Category: Porciero, S]] |
| - | [[Category: Roussel, A | + | [[Category: Roussel, A]] |
| - | [[Category: Tahir, T | + | [[Category: Tahir, T]] |
| - | [[Category: Williamson, G | + | [[Category: Williamson, G]] |
[[Category: Hydrolase inhibitor-hydrolase complex]] | [[Category: Hydrolase inhibitor-hydrolase complex]] | ||
Revision as of 21:28, 24 December 2014
Crystal Structure of xylanase (GH10) in complex with inhibitor (XIP)
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