1xpo

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xpo]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XPO FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xpo]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XPO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=BCM:BICYCLOMYCIN'>BCM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=BCM:BICYCLOMYCIN'>BCM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xpr|1xpr]], [[1xpu|1xpu]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xpr|1xpr]], [[1xpu|1xpu]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xpo RCSB], [http://www.ebi.ac.uk/pdbsum/1xpo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xpo RCSB], [http://www.ebi.ac.uk/pdbsum/1xpo PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MEMA_METCA MEMA_METCA]] Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Berger, J M.]]
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[[Category: Berger, J M]]
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[[Category: Brogan, A P.]]
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[[Category: Brogan, A P]]
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[[Category: Kohn, H.]]
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[[Category: Kohn, H]]
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[[Category: Park, B S.]]
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[[Category: Park, B S]]
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[[Category: Skordalakes, E.]]
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[[Category: Skordalakes, E]]
[[Category: Bicyclomycin]]
[[Category: Bicyclomycin]]
[[Category: Rho]]
[[Category: Rho]]
[[Category: Transcription-rna complex]]
[[Category: Transcription-rna complex]]

Revision as of 22:21, 25 December 2014

Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin

1xpo, resolution 3.15Å

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