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1y7x
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br> | <table><tr><td colspan='2'>[[1y7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7X FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7x RCSB], [http://www.ebi.ac.uk/pdbsum/1y7x PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MVP_HUMAN MVP_HUMAN]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.<ref>PMID:15133037</ref> <ref>PMID:16441665</ref> <ref>PMID:16418217</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Banville, D | + | [[Category: Banville, D]] |
| - | [[Category: Ekiel, I | + | [[Category: Ekiel, I]] |
| - | [[Category: Gehring, K | + | [[Category: Gehring, K]] |
| - | [[Category: Kozlov, G | + | [[Category: Kozlov, G]] |
| - | [[Category: Minailiuc, O | + | [[Category: Minailiuc, O]] |
| - | [[Category: Vavelyuk, O | + | [[Category: Vavelyuk, O]] |
[[Category: Beta-sheet module]] | [[Category: Beta-sheet module]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
[[Category: Structural repeat]] | [[Category: Structural repeat]] | ||
Revision as of 14:44, 25 December 2014
Solution structure of a two-repeat fragment of major vault protein
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