1wr0

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr0 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wr0 TOPSAN]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wr0 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr0 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wr0 TOPSAN]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/VPS4B_HUMAN VPS4B_HUMAN]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<ref>PMID:11563910</ref> <ref>PMID:14505570</ref> <ref>PMID:18687924</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fujiwara, K.]]
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[[Category: Fujiwara, K]]
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[[Category: Goda, N.]]
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[[Category: Goda, N]]
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[[Category: Hiroaki, H.]]
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[[Category: Hiroaki, H]]
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[[Category: Jee, J G.]]
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[[Category: Jee, J G]]
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[[Category: Ohno, A.]]
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[[Category: Ohno, A]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Structural genomic]]
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[[Category: Shirakawa, M.]]
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[[Category: Shirakawa, M]]
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[[Category: Takasu, H.]]
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[[Category: Takasu, H]]
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[[Category: Tochio, H.]]
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[[Category: Tochio, H]]
[[Category: Escort]]
[[Category: Escort]]
[[Category: Mit domain]]
[[Category: Mit domain]]
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[[Category: Nppsfa]]
[[Category: Nppsfa]]
[[Category: Protein transport]]
[[Category: Protein transport]]
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[[Category: Riken structural genomics/proteomics initiative]]
 
[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Skd1]]
[[Category: Skd1]]
[[Category: Snp]]
[[Category: Snp]]
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[[Category: Structural genomic]]
 
[[Category: Vps4b]]
[[Category: Vps4b]]

Revision as of 16:55, 24 December 2014

Structural characterization of the MIT domain from human Vps4b

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