1vf6
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1vf6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VF6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1vf6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VF6 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rso|1rso]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rso|1rso]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vf6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vf6 RCSB], [http://www.ebi.ac.uk/pdbsum/1vf6 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vf6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vf6 RCSB], [http://www.ebi.ac.uk/pdbsum/1vf6 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/INADL_HUMAN INADL_HUMAN]] Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.<ref>PMID:11927608</ref> [[http://www.uniprot.org/uniprot/MPP5_MOUSE MPP5_MOUSE]] May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton.<ref>PMID:15677456</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Karnak, D | + | [[Category: Karnak, D]] |
| - | [[Category: Lavie, A | + | [[Category: Lavie, A]] |
| - | [[Category: Li, Y | + | [[Category: Li, Y]] |
| - | [[Category: Margolis, B | + | [[Category: Margolis, B]] |
[[Category: Coiled-coil]] | [[Category: Coiled-coil]] | ||
[[Category: Four-helical bundle]] | [[Category: Four-helical bundle]] | ||
Revision as of 15:04, 25 December 2014
2.1 Angstrom crystal structure of the PALS-1-L27N and PATJ L27 heterodimer complex
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