1hkx
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1hkx |SIZE=350|CAPTION= <scene name='initialview01'>1hkx</scene>, resolution 2.65Å | |PDB= 1hkx |SIZE=350|CAPTION= <scene name='initialview01'>1hkx</scene>, resolution 2.65Å | ||
|SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+N'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+N'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene> | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/ | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkx OCA], [http://www.ebi.ac.uk/pdbsum/1hkx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hkx RCSB]</span> | ||
}} | }} | ||
| Line 20: | Line 23: | ||
==Reference== | ==Reference== | ||
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II., Hoelz A, Nairn AC, Kuriyan J, Mol Cell. 2003 May;11(5):1241-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12769848 12769848] | Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II., Hoelz A, Nairn AC, Kuriyan J, Mol Cell. 2003 May;11(5):1241-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12769848 12769848] | ||
| + | [[Category: Calcium/calmodulin-dependent protein kinase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Transferred entry: 2 7.11 17]] | ||
[[Category: Hoelz, A.]] | [[Category: Hoelz, A.]] | ||
[[Category: Kuriyan, J.]] | [[Category: Kuriyan, J.]] | ||
[[Category: Nairn, A C.]] | [[Category: Nairn, A C.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: DTT]] | ||
| - | [[Category: TBR]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
| Line 36: | Line 36: | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:06:57 2008'' |
Revision as of 18:06, 30 March 2008
| |||||||
| , resolution 2.65Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Activity: | Calcium/calmodulin-dependent protein kinase, with EC number 2.7.11.17 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE
Overview
We report the crystal structure of the 143 residue association domain of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). The association domain forms a hub-like assembly, composed of two rings of seven protomers each, which are stacked head to head and held together by extensive interfaces. The tetradecameric organization of the assembly was confirmed by analytical ultracentrifugation and multiangle light scattering. Individual protomers form wedge-shaped structures from which N-terminal helical segments that connect to the kinase domain extend toward the equatorial plane of the assembly, consistent with the arrangement of the kinase domains in a second outer ring. A deep and highly conserved pocket present within the association domain may serve as a docking site for proteins that interact with CaMKII.
About this Structure
1HKX is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II., Hoelz A, Nairn AC, Kuriyan J, Mol Cell. 2003 May;11(5):1241-51. PMID:12769848
Page seeded by OCA on Sun Mar 30 21:06:57 2008
