2ahe
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ahe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AHE FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ahe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AHE FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k0m|1k0m]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k0m|1k0m]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ahe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ahe RCSB], [http://www.ebi.ac.uk/pdbsum/2ahe PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ahe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ahe RCSB], [http://www.ebi.ac.uk/pdbsum/2ahe PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CLIC4_HUMAN CLIC4_HUMAN]] Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).<ref>PMID:12163372</ref> <ref>PMID:14569596</ref> <ref>PMID:16239224</ref> <ref>PMID:18302930</ref> <ref>PMID:19247789</ref> <ref>PMID:16176272</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Aguilar, M I | + | [[Category: Aguilar, M I]] |
| - | [[Category: Assaad, N N | + | [[Category: Assaad, N N]] |
| - | [[Category: Berryman, M A | + | [[Category: Berryman, M A]] |
| - | [[Category: Breit, S N | + | [[Category: Breit, S N]] |
| - | [[Category: Brown, L J | + | [[Category: Brown, L J]] |
| - | [[Category: Curmi, P M.G | + | [[Category: Curmi, P M.G]] |
| - | [[Category: Harrop, S J | + | [[Category: Harrop, S J]] |
| - | [[Category: Littler, D R | + | [[Category: Littler, D R]] |
| - | [[Category: Luciani, P | + | [[Category: Luciani, P]] |
| - | [[Category: Mazzanti, M | + | [[Category: Mazzanti, M]] |
| - | [[Category: Pankhurst, G J | + | [[Category: Pankhurst, G J]] |
[[Category: Chloride ion channel]] | [[Category: Chloride ion channel]] | ||
[[Category: Clic4]] | [[Category: Clic4]] | ||
Revision as of 02:47, 25 December 2014
Crystal structure of a soluble form of CLIC4. intercellular chloride ion channel
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