1hlb
From Proteopedia
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|PDB= 1hlb |SIZE=350|CAPTION= <scene name='initialview01'>1hlb</scene>, resolution 2.5Å | |PDB= 1hlb |SIZE=350|CAPTION= <scene name='initialview01'>1hlb</scene>, resolution 2.5Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene> | + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hlb OCA], [http://www.ebi.ac.uk/pdbsum/1hlb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hlb RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HLB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 1HLB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caudina_arenicola Caudina arenicola]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLB OCA]. |
==Reference== | ==Reference== | ||
Structural analysis of monomeric hemichrome and dimeric cyanomet hemoglobins from Caudina arenicola., Mitchell DT, Kitto GB, Hackert ML, J Mol Biol. 1995 Aug 18;251(3):421-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7650740 7650740] | Structural analysis of monomeric hemichrome and dimeric cyanomet hemoglobins from Caudina arenicola., Mitchell DT, Kitto GB, Hackert ML, J Mol Biol. 1995 Aug 18;251(3):421-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7650740 7650740] | ||
| + | [[Category: Caudina arenicola]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Thermomicrobium roseum]] | ||
[[Category: Hackert, M L.]] | [[Category: Hackert, M L.]] | ||
[[Category: Mitchell, D T.]] | [[Category: Mitchell, D T.]] | ||
| - | [[Category: HEM]] | ||
[[Category: oxygen transport]] | [[Category: oxygen transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:07:08 2008'' |
Revision as of 18:07, 30 March 2008
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| , resolution 2.5Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
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Overview
The X-ray structures of two hemoglobins (Hb) from the sea cucumber Caudina arenicola (an echinoderm) have been determined: a low spin, hemichrome, monomeric Hb-C chain, and a cyanomet-liganded dimeric Hb-D chain. Attempts to obtain crystal structures of the deoxy-liganded and hemichrome forms from the same chain type have not been successful. In this work, the Hb-C chain and Hb-D chain structures are compared, and differences observed in tertiary structure related to the different ligand states for hemoglobin chains from this organism. In addition to shifts of the distal histidine and E helix, differences are noted in the position of the heme group within the heme pocket, the hydrogen bonding of the heme group to the protein, and the status of the D helix. These differences are important in understanding the ligand-linked association states of these hemoglobins. The quaternary structure of the Hb-D homodimer is compared with those from two other invertebrate hemoglobins from Scapharca inaequivalvis and Urechis caupo, which also have subunit-subunit interactions that involve the E and E' helices. The dimer interactions of the Caudina and Urechis hemoglobins are quite dissimilar. However, the dimer interface observed in cyanomet Hb-D is strikingly similar to that observed for the carbonmonoxy hemoglobin dimer from the clam, Scapharca, yet many of the key amino acid residues implicated in the cooperative mechanism of the Scapharca hemoglobin are not conserved in the Caudina hemoglobins.
About this Structure
1HLB is a Single protein structure of sequence from Caudina arenicola. Full crystallographic information is available from OCA.
Reference
Structural analysis of monomeric hemichrome and dimeric cyanomet hemoglobins from Caudina arenicola., Mitchell DT, Kitto GB, Hackert ML, J Mol Biol. 1995 Aug 18;251(3):421-31. PMID:7650740
Page seeded by OCA on Sun Mar 30 21:07:08 2008
