2a55

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2a55]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A55 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2a55]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A55 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C4BPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C4BPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a55 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a55 RCSB], [http://www.ebi.ac.uk/pdbsum/2a55 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a55 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a55 RCSB], [http://www.ebi.ac.uk/pdbsum/2a55 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/C4BP_HUMAN C4BP_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ball, G.]]
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[[Category: Ball, G]]
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[[Category: Barlow, P N.]]
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[[Category: Barlow, P N]]
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[[Category: Blom, A M.]]
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[[Category: Blom, A M]]
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[[Category: Jenkins, H T.]]
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[[Category: Jenkins, H T]]
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[[Category: Lindahl, G.]]
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[[Category: Lindahl, G]]
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[[Category: Mark, L.]]
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[[Category: Mark, L]]
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[[Category: Uhrin, D.]]
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[[Category: Uhrin, D]]
[[Category: Ccp module]]
[[Category: Ccp module]]
[[Category: Complement]]
[[Category: Complement]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Scr]]
[[Category: Scr]]

Revision as of 17:12, 25 December 2014

Solution structure of the two N-terminal CCP modules of C4b-binding protein (C4BP) alpha-chain.

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