2e1o
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2e1o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wqi 1wqi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E1O FirstGlance]. <br> | <table><tr><td colspan='2'>[[2e1o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wqi 1wqi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E1O FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HHEX, HEX, PRH, PRHX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HHEX, HEX, PRH, PRHX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e1o RCSB], [http://www.ebi.ac.uk/pdbsum/2e1o PDBsum], [http://www.topsan.org/Proteins/RSGI/2e1o TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e1o RCSB], [http://www.ebi.ac.uk/pdbsum/2e1o PDBsum], [http://www.topsan.org/Proteins/RSGI/2e1o TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HHEX_HUMAN HHEX_HUMAN]] Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Abe, T | + | [[Category: Abe, T]] |
| - | [[Category: Hirota, H | + | [[Category: Hirota, H]] |
| - | [[Category: Kawaii, S | + | [[Category: Kawaii, S]] |
| - | [[Category: Kigawa, T | + | [[Category: Kigawa, T]] |
| - | [[Category: Koshiba, S | + | [[Category: Koshiba, S]] |
| - | [[Category: Nakamura, A | + | [[Category: Nakamura, A]] |
| - | [[Category: Nameki, N | + | [[Category: Nameki, N]] |
| - | [[Category: Ohnishi, S | + | [[Category: Ohnishi, S]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Tochio, N | + | [[Category: Tochio, N]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 14:28, 24 December 2014
Solution structure of RSGI RUH-028, a homeobox domain from human cDNA
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