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2c6a
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c6a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C6A FirstGlance]. <br> | <table><tr><td colspan='2'>[[2c6a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C6A FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rv1|1rv1]], [[1t4e|1t4e]], [[1t4f|1t4f]], [[1ycr|1ycr]], [[1z1m|1z1m]], [[2c6b|2c6b]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rv1|1rv1]], [[1t4e|1t4e]], [[1t4f|1t4f]], [[1ycr|1ycr]], [[1z1m|1z1m]], [[2c6b|2c6b]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c6a RCSB], [http://www.ebi.ac.uk/pdbsum/2c6a PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c6a RCSB], [http://www.ebi.ac.uk/pdbsum/2c6a PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | [[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Allen, M D | + | [[Category: Allen, M D]] |
| - | [[Category: Andreeva, A | + | [[Category: Andreeva, A]] |
| - | [[Category: Bycroft, M | + | [[Category: Bycroft, M]] |
| - | [[Category: Fersht, A R | + | [[Category: Fersht, A R]] |
| - | [[Category: Yu, G W | + | [[Category: Yu, G W]] |
[[Category: Human mdm2]] | [[Category: Human mdm2]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 16:46, 15 January 2015
SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2
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