1hnw
From Proteopedia
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|PDB= 1hnw |SIZE=350|CAPTION= <scene name='initialview01'>1hnw</scene>, resolution 3.40Å | |PDB= 1hnw |SIZE=350|CAPTION= <scene name='initialview01'>1hnw</scene>, resolution 3.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAC:TETRACYCLINE'>TAC</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1qd7|1QD7]], [[1fjf|1FJF]], [[1fjg|1FJG]], [[1hnx|1HNX]], [[1hnz|1HNZ]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hnw OCA], [http://www.ebi.ac.uk/pdbsum/1hnw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hnw RCSB]</span> | ||
}} | }} | ||
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[[Category: Ramakrishnan, V.]] | [[Category: Ramakrishnan, V.]] | ||
[[Category: Wimberly, B T.]] | [[Category: Wimberly, B T.]] | ||
| - | [[Category: MG]] | ||
| - | [[Category: TAC]] | ||
| - | [[Category: ZN]] | ||
[[Category: 30s ribosomal subunit]] | [[Category: 30s ribosomal subunit]] | ||
[[Category: antibiotic]] | [[Category: antibiotic]] | ||
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[[Category: tetracycline]] | [[Category: tetracycline]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:08:09 2008'' |
Revision as of 18:08, 30 March 2008
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| , resolution 3.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , , | ||||||
| Related: | 1QD7, 1FJF, 1FJG, 1HNX, 1HNZ
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE
Overview
We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function.
About this Structure
1HNW is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.
Reference
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit., Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V, Cell. 2000 Dec 22;103(7):1143-54. PMID:11163189
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