2bmj
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BMJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[2bmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BMJ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bmj RCSB], [http://www.ebi.ac.uk/pdbsum/2bmj PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bmj RCSB], [http://www.ebi.ac.uk/pdbsum/2bmj PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CENG1_HUMAN CENG1_HUMAN]] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C | + | [[Category: Arrowsmith, C]] |
| - | [[Category: Doyle, D A | + | [[Category: Doyle, D A]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Elkins, J M | + | [[Category: Elkins, J M]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Soundararajan, M | + | [[Category: Soundararajan, M]] |
| - | [[Category: Sundstrom, M | + | [[Category: Sundstrom, M]] |
| - | [[Category: Yang, X | + | [[Category: Yang, X]] |
[[Category: Centaurin ank repeat]] | [[Category: Centaurin ank repeat]] | ||
[[Category: Gtp-binding]] | [[Category: Gtp-binding]] | ||
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[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Revision as of 11:38, 25 December 2014
GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
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