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2b7f
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2b7f]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7F FirstGlance]. <br> | <table><tr><td colspan='2'>[[2b7f]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7F FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7f RCSB], [http://www.ebi.ac.uk/pdbsum/2b7f PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7f RCSB], [http://www.ebi.ac.uk/pdbsum/2b7f PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VPRT_HTL1A VPRT_HTL1A]] Matrix protein p19 targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity).<ref>PMID:2843670</ref> Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).<ref>PMID:2843670</ref> Nucleocapsid protein p15 is involved in the packaging and encapsidation of two copies of the genome (By similarity).<ref>PMID:2843670</ref> The aspartyl protease mediates proteolytic cleavages of Gag, Gag-Pro and Gag-Pro-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).<ref>PMID:2843670</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human t-lymphotropic virus 1]] | [[Category: Human t-lymphotropic virus 1]] | ||
| - | [[Category: Alexandratos, J | + | [[Category: Alexandratos, J]] |
| - | [[Category: Gustchina, A | + | [[Category: Gustchina, A]] |
| - | [[Category: Jaskolski, M | + | [[Category: Jaskolski, M]] |
| - | [[Category: Laco, G S | + | [[Category: Laco, G S]] |
| - | [[Category: Li, M | + | [[Category: Li, M]] |
| - | [[Category: Rozycki, J | + | [[Category: Rozycki, J]] |
| - | [[Category: Wlodawer, A | + | [[Category: Wlodawer, A]] |
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
Revision as of 15:18, 24 December 2014
Crystal structure of human T-cell leukemia virus protease, a novel target for anti-cancer design
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