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2ck4
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ck4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CK4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ck4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CK4 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sco|1sco]], [[2ck5|2ck5]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sco|1sco]], [[2ck5|2ck5]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ck4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ck4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ck4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ck4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ck4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ck4 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KAX37_ORTSC KAX37_ORTSC]] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]<ref>PMID:15588251</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Potassium channel toxin|Potassium channel toxin]] | *[[Potassium channel toxin|Potassium channel toxin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Alphonse, S | + | [[Category: Alphonse, S]] |
| - | [[Category: Bernard, C | + | [[Category: Bernard, C]] |
| - | [[Category: Darbon, H | + | [[Category: Darbon, H]] |
| - | [[Category: Mouhat, S | + | [[Category: Mouhat, S]] |
| - | [[Category: Sabatier, J M | + | [[Category: Sabatier, J M]] |
[[Category: Ion channel blocker]] | [[Category: Ion channel blocker]] | ||
[[Category: Ion channel inhibitor]] | [[Category: Ion channel inhibitor]] | ||
Revision as of 10:08, 25 December 2014
SOLUTION STRUCTURE OF AOSK1
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