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2eyy

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2eyy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EYY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2eyy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EYY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eyv|2eyv]], [[2eyw|2eyw]], [[2eyx|2eyx]], [[2eyz|2eyz]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eyv|2eyv]], [[2eyw|2eyw]], [[2eyx|2eyx]], [[2eyz|2eyz]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eyy RCSB], [http://www.ebi.ac.uk/pdbsum/2eyy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eyy RCSB], [http://www.ebi.ac.uk/pdbsum/2eyy PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CRK_HUMAN CRK_HUMAN]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.<ref>PMID:1630456</ref> <ref>PMID:11870224</ref> <ref>PMID:17515907</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inagaki, F.]]
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[[Category: Inagaki, F]]
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[[Category: Kobashigawa, Y.]]
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[[Category: Kobashigawa, Y]]
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[[Category: Tanaka, S.]]
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[[Category: Tanaka, S]]
[[Category: Sh2]]
[[Category: Sh2]]
[[Category: Sh3]]
[[Category: Sh3]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]

Revision as of 21:03, 24 December 2014

CT10-Regulated Kinase isoform I

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