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2dm4
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DM4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2dm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DM4 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2dm4 PDBsum], [http://www.topsan.org/Proteins/RSGI/2dm4 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2dm4 PDBsum], [http://www.topsan.org/Proteins/RSGI/2dm4 TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hayashi, F | + | [[Category: Hayashi, F]] |
| - | [[Category: Kurosaki, C | + | [[Category: Kurosaki, C]] |
| - | [[Category: Nagashima, T | + | [[Category: Nagashima, T]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
| - | [[Category: Yoshida, M | + | [[Category: Yoshida, M]] |
[[Category: Alzheimer's disease]] | [[Category: Alzheimer's disease]] | ||
[[Category: App]] | [[Category: App]] | ||
| Line 34: | Line 36: | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Sorla]] | [[Category: Sorla]] | ||
[[Category: Sorting protein-related receptor containing ldlr class a repeat]] | [[Category: Sorting protein-related receptor containing ldlr class a repeat]] | ||
| - | [[Category: Structural genomic]] | ||
Revision as of 18:45, 24 December 2014
Solution structure of the second fn3 domain of human sorLA/LR11
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Categories: Homo sapiens | Hayashi, F | Kurosaki, C | Nagashima, T | Structural genomic | Yokoyama, S | Yoshida, M | Alzheimer's disease | App | Bace1 | Beta-sandwich | Lipid transport | Low-density lipoprotein receptor relative with 11 ligand-binding repeat | Lr11 | National project on protein structural and functional analyse | Nppsfa | Rsgi | Sorla | Sorting protein-related receptor containing ldlr class a repeat
