2aie
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2aie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIE FirstGlance]. <br> | <table><tr><td colspan='2'>[[2aie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AIE FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SB9:HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE'>SB9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SB9:HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE'>SB9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ai7|2ai7]], [[2ai8|2ai8]], [[2ai9|2ai9]], [[2aia|2aia]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ai7|2ai7]], [[2ai8|2ai8]], [[2ai9|2ai9]], [[2aia|2aia]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">def ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">def ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aie RCSB], [http://www.ebi.ac.uk/pdbsum/2aie PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aie RCSB], [http://www.ebi.ac.uk/pdbsum/2aie PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DEF_STRR6 DEF_STRR6]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Peptide deformylase]] | [[Category: Peptide deformylase]] | ||
[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
| - | [[Category: Aubart, K | + | [[Category: Aubart, K]] |
| - | [[Category: Christensen, S B | + | [[Category: Christensen, S B]] |
| - | [[Category: Fosberry, A | + | [[Category: Fosberry, A]] |
| - | [[Category: Jones, J | + | [[Category: Jones, J]] |
| - | [[Category: Lewis, C | + | [[Category: Lewis, C]] |
| - | [[Category: Lonetto, M | + | [[Category: Lonetto, M]] |
| - | [[Category: McManus, E | + | [[Category: McManus, E]] |
| - | [[Category: Petit, C M | + | [[Category: Petit, C M]] |
| - | [[Category: Smith, K J | + | [[Category: Smith, K J]] |
| - | [[Category: Smyth, M | + | [[Category: Smyth, M]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 10:53, 25 December 2014
S.pneumoniae polypeptide deformylase complexed with SB-505684
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