2ery
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ery]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERY FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ery]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERY FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RRAS2, TC21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RRAS2, TC21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ery FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ery OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ery RCSB], [http://www.ebi.ac.uk/pdbsum/2ery PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ery FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ery OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ery RCSB], [http://www.ebi.ac.uk/pdbsum/2ery PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN]] Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:[http://omim.org/entry/167000 167000]]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. | [[http://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN]] Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:[http://omim.org/entry/167000 167000]]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C | + | [[Category: Arrowsmith, C]] |
| - | [[Category: Burgess, N | + | [[Category: Burgess, N]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Doyle, D | + | [[Category: Doyle, D]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Elkins, J | + | [[Category: Elkins, J]] |
| - | [[Category: Gileadi, C | + | [[Category: Gileadi, C]] |
| - | [[Category: Gileadi, O | + | [[Category: Gileadi, O]] |
| - | [[Category: Papagrigoriou, E | + | [[Category: Papagrigoriou, E]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Salah, E | + | [[Category: Salah, E]] |
| - | [[Category: Schoch, G | + | [[Category: Schoch, G]] |
| - | [[Category: Soundararajan, M | + | [[Category: Soundararajan, M]] |
| - | [[Category: Sundstrom, M | + | [[Category: Sundstrom, M]] |
| - | [[Category: Turnbull, A | + | [[Category: Turnbull, A]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
[[Category: Gdp/gtp binding]] | [[Category: Gdp/gtp binding]] | ||
[[Category: Gtp hydrolysis]] | [[Category: Gtp hydrolysis]] | ||
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[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Revision as of 18:20, 15 January 2015
The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state
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Categories: Homo sapiens | Arrowsmith, C | Burgess, N | Delft, F von | Doyle, D | Edwards, A | Elkins, J | Gileadi, C | Gileadi, O | Papagrigoriou, E | Structural genomic | Salah, E | Schoch, G | Soundararajan, M | Sundstrom, M | Turnbull, A | Weigelt, J | Gdp/gtp binding | Gtp hydrolysis | Rras2 | Sgc | Signaling protein
