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2gvf
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GVF FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GVF FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHN:(6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE'>NHN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHN:(6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE'>NHN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a1r|1a1r]], [[2fm2|2fm2]], [[1rgq|1rgq]], [[2a4g|2a4g]], [[2a4r|2a4r]], [[2a4q|2a4q]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a1r|1a1r]], [[2fm2|2fm2]], [[1rgq|1rgq]], [[2a4g|2a4g]], [[2a4r|2a4r]], [[2a4q|2a4q]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gvf RCSB], [http://www.ebi.ac.uk/pdbsum/2gvf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gvf RCSB], [http://www.ebi.ac.uk/pdbsum/2gvf PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
| - | [[Category: Arasappan, A | + | [[Category: Arasappan, A]] |
| - | [[Category: Butkiewicz, N | + | [[Category: Butkiewicz, N]] |
| - | [[Category: Chen, K X | + | [[Category: Chen, K X]] |
| - | [[Category: Girijavallabhan, V | + | [[Category: Girijavallabhan, V]] |
| - | [[Category: Gu, H | + | [[Category: Gu, H]] |
| - | [[Category: Madison, V | + | [[Category: Madison, V]] |
| - | [[Category: Njoroge, F G | + | [[Category: Njoroge, F G]] |
| - | [[Category: Parekh, T N | + | [[Category: Parekh, T N]] |
| - | [[Category: Pichardo, J | + | [[Category: Pichardo, J]] |
| - | [[Category: Prongay, A | + | [[Category: Prongay, A]] |
| - | [[Category: Venkatraman, S | + | [[Category: Venkatraman, S]] |
[[Category: Hepatitis c]] | [[Category: Hepatitis c]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Ketoamide inhibitor]] | [[Category: Ketoamide inhibitor]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
Revision as of 07:58, 16 January 2015
HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021
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