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2k6s
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k6s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K6S FirstGlance]. <br> | <table><tr><td colspan='2'>[[2k6s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K6S FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rab11fip2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rab11fip2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k6s RCSB], [http://www.ebi.ac.uk/pdbsum/2k6s PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k6s RCSB], [http://www.ebi.ac.uk/pdbsum/2k6s PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RFIP2_HUMAN RFIP2_HUMAN]] A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.<ref>PMID:12364336</ref> <ref>PMID:15304524</ref> <ref>PMID:16775013</ref> <ref>PMID:19542231</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Baleja, J D | + | [[Category: Baleja, J D]] |
| - | [[Category: Liu, Y | + | [[Category: Liu, Y]] |
| - | [[Category: Wei, J | + | [[Category: Wei, J]] |
[[Category: Coiled-coil domain]] | [[Category: Coiled-coil domain]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Rab11-fip2]] | [[Category: Rab11-fip2]] | ||
[[Category: Solution structure]] | [[Category: Solution structure]] | ||
Revision as of 02:41, 25 December 2014
Structure of Rab11-FIP2 C-terminal Coiled-coil Domain
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