2irf
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IRF FirstGlance]. <br> | <table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IRF FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE]] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Fujii, Y | + | [[Category: Fujii, Y]] |
| - | [[Category: Hakoshima, T | + | [[Category: Hakoshima, T]] |
| - | [[Category: Kusumoto, M | + | [[Category: Kusumoto, M]] |
| - | [[Category: Kyogoku, Y | + | [[Category: Kyogoku, Y]] |
| - | [[Category: Shimizu, T | + | [[Category: Shimizu, T]] |
| - | [[Category: Taniguchi, T | + | [[Category: Taniguchi, T]] |
[[Category: Gene regulation-dna complex]] | [[Category: Gene regulation-dna complex]] | ||
[[Category: Ifn induction]] | [[Category: Ifn induction]] | ||
[[Category: Irf family]] | [[Category: Irf family]] | ||
[[Category: Transcription factor]] | [[Category: Transcription factor]] | ||
Revision as of 19:08, 25 December 2014
CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
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