This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2hlc
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hypoderma_lineatum Hypoderma lineatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HLC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2hlc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hypoderma_lineatum Hypoderma lineatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HLC FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hlc RCSB], [http://www.ebi.ac.uk/pdbsum/2hlc PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hlc RCSB], [http://www.ebi.ac.uk/pdbsum/2hlc PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COGS_HYPLI COGS_HYPLI]] This enzyme is a serine protease capable of degrading the native triple helix of collagen. Also cleaves the B chain of insulin at the 15-Leu-|-Try-16 and 22-Arg-|-Gly-23 bonds. Hydrolyzes casein, but not Px-Pro-Leu-Gly-Pro-DArg, BzArgNHPh, AcTyrNHPh, 2-naphthyl phosphate, 2-naphthyl butyrate, 2-naphthyl caprylate, 2-naphthyl myristate, L-leucine 2-2-naphthylamide, L-valine 2-naphthylamide, L-cysteine 2-naphthylamide or L-glutarylphenylalanine 2-naphthylamide.<ref>PMID:230030</ref> <ref>PMID:2995028</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 28: | Line 30: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Hypoderma lineatum]] | [[Category: Hypoderma lineatum]] | ||
| - | [[Category: Arnoux, B | + | [[Category: Arnoux, B]] |
| - | [[Category: Broutin, I | + | [[Category: Broutin, I]] |
| - | [[Category: Ducruix, A | + | [[Category: Ducruix, A]] |
| - | [[Category: Merigeau, K | + | [[Category: Merigeau, K]] |
[[Category: Collagen degradation]] | [[Category: Collagen degradation]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
Revision as of 07:12, 24 December 2014
HL COLLAGENASE STRUCTURE AT 1.7A RESOLUTION
| |||||||||||
