2j0n

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2j0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J0N FirstGlance]. <br>
<table><tr><td colspan='2'>[[2j0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J0N FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j0o|2j0o]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j0o|2j0o]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j0n RCSB], [http://www.ebi.ac.uk/pdbsum/2j0n PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j0n RCSB], [http://www.ebi.ac.uk/pdbsum/2j0n PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/IPAD_SHIFL IPAD_SHIFL]] Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore in the host membrane that allows the translocation of the other effectors into the host cytoplasm. Along with IpaB, is essential for both blocking secretion through the Mxi/Spa translocon in the absence of a secretion-inducing signal, and for controlling the level of secretion in the presence of this signal.<ref>PMID:7957095</ref> <ref>PMID:15731041</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Johnson, S.]]
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[[Category: Johnson, S]]
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[[Category: Lea, S M.]]
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[[Category: Lea, S M]]
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[[Category: Roversi, P.]]
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[[Category: Roversi, P]]
[[Category: Cell invasion]]
[[Category: Cell invasion]]
[[Category: Ipad]]
[[Category: Ipad]]
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[[Category: Shigella flexneri]]
 
[[Category: T3ss]]
[[Category: T3ss]]
[[Category: Type iii secretion]]
[[Category: Type iii secretion]]
[[Category: Virulence]]
[[Category: Virulence]]

Revision as of 02:58, 25 December 2014

A PROTEOLYTICALLY TRUNCATED FORM OF SHIGELLA FLEXNERI IPAD

2j0n, resolution 2.10Å

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