2h28
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2h28]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H28 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2h28]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H28 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yeeU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yeeU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h28 RCSB], [http://www.ebi.ac.uk/pdbsum/2h28 PDBsum], [http://www.topsan.org/Proteins/NESGC/2h28 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h28 RCSB], [http://www.ebi.ac.uk/pdbsum/2h28 PDBsum], [http://www.topsan.org/Proteins/NESGC/2h28 TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/YEEU_ECOLI YEEU_ECOLI]] Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes (PubMed:14594833); the intergenic region was not found to be necessary in (PubMed:22515815). Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape.<ref>PMID:14594833</ref> <ref>PMID:22515815</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Acton, T B | + | [[Category: Acton, T B]] |
| - | [[Category: Arbing, M | + | [[Category: Arbing, M]] |
| - | [[Category: Benach, J | + | [[Category: Benach, J]] |
| - | [[Category: Chen, C X | + | [[Category: Chen, C X]] |
| - | [[Category: Cunningham, K | + | [[Category: Cunningham, K]] |
| - | [[Category: Hunt, J F | + | [[Category: Hunt, J F]] |
| - | [[Category: Jiang, M | + | [[Category: Jiang, M]] |
| - | [[Category: Karpowich, N K | + | [[Category: Karpowich, N K]] |
| - | [[Category: Ma, L C | + | [[Category: Ma, L C]] |
| - | [[Category: Montelione, G T | + | [[Category: Montelione, G T]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Su, M | + | [[Category: Su, M]] |
| - | [[Category: Tong, L | + | [[Category: Tong, L]] |
| - | [[Category: Xiao, R | + | [[Category: Xiao, R]] |
[[Category: E. coli]] | [[Category: E. coli]] | ||
[[Category: Er304]] | [[Category: Er304]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
| - | [[Category: | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 15:07, 24 December 2014
Crystal structure of YeeU from E. coli. Northeast Structural Genomics target ER304
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Categories: Escherichia coli | Acton, T B | Arbing, M | Benach, J | Chen, C X | Cunningham, K | Hunt, J F | Jiang, M | Karpowich, N K | Ma, L C | Montelione, G T | Structural genomic | Su, M | Tong, L | Xiao, R | E. coli | Er304 | Nesg | PSI, Protein structure initiative | Unknown function
