2j6o
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2j6o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J6O FirstGlance]. <br> | <table><tr><td colspan='2'>[[2j6o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J6O FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cdb|1cdb]], [[1gya|1gya]], [[1hnf|1hnf]], [[1l2z|1l2z]], [[2bz8|2bz8]], [[2j6f|2j6f]], [[2j6k|2j6k]], [[2j7i|2j7i]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cdb|1cdb]], [[1gya|1gya]], [[1hnf|1hnf]], [[1l2z|1l2z]], [[2bz8|2bz8]], [[2j6f|2j6f]], [[2j6k|2j6k]], [[2j7i|2j7i]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j6o RCSB], [http://www.ebi.ac.uk/pdbsum/2j6o PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j6o RCSB], [http://www.ebi.ac.uk/pdbsum/2j6o PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN]] Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:[http://omim.org/entry/607832 607832]]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:12764198</ref> | [[http://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN]] Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:[http://omim.org/entry/607832 607832]]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:12764198</ref> | ||
| Line 36: | Line 36: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bravo, J | + | [[Category: Bravo, J]] |
| - | [[Category: Cardenes, N | + | [[Category: Cardenes, N]] |
| - | [[Category: Deribe, Y L | + | [[Category: Deribe, Y L]] |
| - | [[Category: Dikic, I | + | [[Category: Dikic, I]] |
| - | [[Category: Moncalian, G | + | [[Category: Moncalian, G]] |
| - | [[Category: Spinola-Amilibia, M | + | [[Category: Spinola-Amilibia, M]] |
[[Category: Adaptor protein]] | [[Category: Adaptor protein]] | ||
[[Category: Cm]] | [[Category: Cm]] | ||
Revision as of 15:55, 19 January 2015
ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETEROTRIMER
| |||||||||||
