2i0l
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2i0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I0L FirstGlance]. <br> | <table><tr><td colspan='2'>[[2i0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I0L FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i0l RCSB], [http://www.ebi.ac.uk/pdbsum/2i0l PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i0l RCSB], [http://www.ebi.ac.uk/pdbsum/2i0l PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG1_RAT DLG1_RAT]] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.<ref>PMID:14960569</ref> <ref>PMID:15044483</ref> <ref>PMID:15504326</ref> <ref>PMID:19213956</ref> [[http://www.uniprot.org/uniprot/VE6_HPV18 VE6_HPV18]] Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Banks, L | + | [[Category: Banks, L]] |
| - | [[Category: Chen, X S | + | [[Category: Chen, X S]] |
| - | [[Category: Dasgupta, J | + | [[Category: Dasgupta, J]] |
| - | [[Category: Thomas, M | + | [[Category: Thomas, M]] |
| - | [[Category: Zhang, Y | + | [[Category: Zhang, Y]] |
[[Category: Carcinoma]] | [[Category: Carcinoma]] | ||
[[Category: Hpv18 e6]] | [[Category: Hpv18 e6]] | ||
Revision as of 05:47, 25 December 2014
X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6.
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